The ACS-4 multi-channel small animal anesthesia machine is an upgraded integrated multi-channel anesthesia machine designed specifically for multi-channel experimental needs. With one induction pathway and four maintenance pathways, up to four animals can be maintained under anesthesia simultaneously, and induction anesthesia can be performed simultaneously. It can better meet the needs of multi-channel experiments for experimenters.
Inhalation anesthesia has become the mainstream animal anesthesia method internationally in recent years due to its advantages of rapid recovery, easy control, high surgical success rate, almost no involvement in metabolism, and compliance with international animal welfare standards. It has been widely used by researchers worldwide. Animal experiments conducted using inhalation anesthesia techniques are more likely to be recognized by international peers for their research results.
With the increasing popularity of inhalation anesthesia, researchers have gradually increased their demand for portability, efficiency, and fluency in the use of inhalation anesthesia. With a deep consideration of this demand, Yuyan Instrument has repeatedly optimized and improved the original ABS (Anesthesia Basic System) series inhalation anesthesia system, and has specially launched a new ACS compact inhalation anesthesia system to optimize the user experience of inhalation anesthesia.
The core components of Yuyan Instrument's inhalation anesthesia system are imported volatilization tanks that comply with IS09001 and European CE quality certification. They are calibrated separately at the factory, and the volatilization of anesthetics is not affected by factors such as temperature, humidity, and pressure. The concentration is uniform and stable, and the safety factor for animals is high. It is very suitable for various small and medium-sized experimental animals such as mice, rats, and guinea pigs.
Main features:
1. Imported tank body, stable and sealed
The anesthesia canister is imported with original packaging and has high-precision temperature compensation function. The output accuracy is 0.1%, the output is stable, the sealing is good, and it is safe and reliable; Output concentration adjustable from 0-5%;

Accurate glass tube oxygen flow meter, with a total flow adjustment range of 0-4000 milliliters per minute and a single channel flow adjustment range of 0-100 milliliters per minute. The flow rate is precisely adjustable and suitable for low flow anesthesia of small animals. The flowmeter has a digital amplification function, making observation clearer and more convenient;
3. Induce and maintain independent control, "true" four channel anesthesia machine
The ACS-4A anesthesia machine adopts an induction and maintenance independent control design, which means that induction anesthesia is controlled separately and does not occupy the maintenance anesthesia channel. Compared with ABS-4A and its competitors, it can have an additional complete anesthesia channel and can achieve induction and maintenance simultaneously, improving experimental efficiency.
Application scenario: Pipeline experiments such as live imaging require induction and multi-channel maintenance anesthesia to be performed simultaneously
4. Maintain independent control of channel flow
The four maintenance anesthesia channels of ACS-4A can independently control the airflow, and the experimenters can adjust them independently in real time according to the animal's weight and anesthesia status, maximizing the utilization rate of anesthetics and saving anesthetics. In addition, independent flow control can also achieve simultaneous experiments of multiple species.
Application scenario: Different experimenters conduct experiments on different species of animals simultaneously; Animal experiments on different weight ranges, etc
5. Rapid oxygenation and rapid removal of anesthesia waste gas
Integrated rapid oxygenation function, capable of quickly expelling anesthetic gas from the induction box to prevent experimenters from accidentally inhaling anesthetic drugs when removing animals, effectively protecting experimenters.
model: ACS-4A
Application areas:
Anesthesia suitable for various animal experiments
Injection experiment:Injections such as viruses, cells, drugs, etc
Live imaging:MRI, CT, X-ray and other imaging techniques
Physiological research:Optogenetics, electrophysiological experiments, calcium imaging, microdialysis, etc
Model making:MCAO model, spinal cord injury, myocardial ischemia, etc
other:Animal euthanasia, eye blood collection, tumor size measurement, etc
Main components:
Animal anesthesia machine host
·Imported with original packaging, available in two styles of volatile cans: isoflurane and sevoflurane
·High output accuracy, with temperature compensation function, can accurately control the output concentration of drugs
·Equipped with a safety locking device to prevent accidental evaporation of medication
Oxygen flow controller
·Two oxygen flow adjustment ranges are available: 0.2-1 liters/minute and 0.4-4 liters/minute
·Rotary control, convenient and easy to use, precise control
Pneumatic controlvalve
·Air circuit adjustment switch, no need to adjust the pipeline, easy to switch freely between inducing anesthesia and maintaining anesthesia
Anesthesia induction box
·Inducing anesthesia on experimental animals, the box is made of transparent acrylic material, making it easy to observe the animals
·Multiple sizes of induction boxes are available for selection, and personalized customization can also be made according to needs
Animal surgical board
·Equipped with a double-layer anesthesia mask
·PE material, with fixing bolts on both sides for easy fixation of mice
·There are two sizes to choose from: rat and mouse
Exhaust gas filtration tank
·Made of granular activated carbon, it can efficiently adsorb anesthesia waste gas
·Connect the anesthesia induction box for use, reducing the emission of high concentration anesthesia waste gas
As needed, optional:
Negative pressure exhaust gas processor
·Accurate and adjustable adsorption flow rate
·Dual tank adsorption, better effect, can remove 98% of anesthesia waste gas
·Large capacity tank with high adsorption capacity for anesthetic waste gas and long replacement cycle
·Activated carbon is easy to replace and has low usage costs
·More worry free to use, with activated carbon cumulative timing function
Multi channel anesthesia component
If anesthesia surgery is required for multiple animals, multi-channel components can be used to achieve anesthesia control for 2, 3, 4, and 5 mice simultaneously.
Multi functional solution:
Neuroscience application plan:
Solution for respiratory and anesthesia combination:
Installation case
Partial references:
1. Lu, Zhenyao, et al. 'Quantitative analysis of 20 purine and pyrimidine metabolites by HILIC-MS/MS in the serum and hippocampus of depressed mice.' Journal of Pharmaceutical and Biomedical Analysis 219 (2022): 114886. doi: 10.1016/j.jpba.2022.114886
2. Ma, Peipei, et al. 'Wound healing of laser injured skin with glycerol monooleicate cubic liquid crystal.' Burns 46.6 (2020): 1381-1388. doi: 10.1016/j.burns.2020.03.016
3. Sun, Xian, et al. 'Yishen Qingli Heluo granule in the treatment of chronic kidney disease: network pharmacology analysis and experimental validation.' Drug Design, Development and Therapy (2022): 769-787. doi: 10.2147/dddt.s348335
4. Sun, Xian, et al. 'Yishen Qingli Heluo granule ameliorates renal dysfunction in 5/6 nephrectomized rats by targeting gut microbiota and intestinal barrier integrity.' Frontiers in Pharmacology 13 (2022). doi: 10.3389/fphar.2022.858881
5. Zhao, Xiaoye, et al. 'An injectable and antifouling self-fused supramolecular hydrogel for preventing postoperative and recurrent adhesions.' Chemical Engineering Journal 404 (2021): 127096. doi: 10.1016/j.cej.2020.127096
6. Liu, Bin, et al. 'JS-K, a nitric oxide donor, induces autophagy as a complementary mechanism inhibiting ovarian cancer.' BMC cancer 19.1 (2019): 1-15. doi: 10.1186/s12885-019-5619-z
7. Li, Xiaozhou, et al. 'Antibacterial, antioxidant and biocompatible nanosized quercetin-PVA xerogel films for wound dressing.' Colloids and Surfaces B: Biointerfaces 209 (2022): 112175. doi: 10.1016/j.colsurfb.2021.112175
8. Kan, Mo, et al. 'Investigating the mechanism of ShengmaiYin (codonopsis pilosula) in the treatment of heart failure based on network pharmacology.' Combinatorial Chemistry & High Throughput Screening 25.13 (2022): 2191-2202. doi: 10.2174/1386207325666220221093415
9. Chen, Yongli, et al. 'Microfluidic chip interfacing microdialysis and mass spectrometry for in vivo monitoring of nanomedicine pharmacokinetics in real time.' Journal of Chromatography A 1683 (2022): 463520. doi: 10.2139/ssrn.4053570
10. Jia, HuiJie, et al. 'Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro.' Biochemical and Biophysical Research Communications 638 (2023): 103-111. doi: 10.1016/j.bbrc.2022.11.035
11. Su Pengliang, Shen Mingqin, Xu Youqi The inhibitory effect and mechanism of Jianpi Huoxue Formula on liver cancer in situ transplantation Journal of Integrated Traditional Chinese and Western Medicine, November 2021, 30 (33)
12. Zhang Jiaojiao, Xie Chenlong, Yong Yue, etc The effect and mechanism of electroacupuncture on long-term survival rate of mice after myocardial infarction Acupuncture Research, Volume 47, Issue 3, March 2022
13. Tang Qianqian, Lu Shan, Jiang Minhai Preparation and evaluation of permanent left middle cerebral artery occlusion model in SCID mice Zhejiang Medical, Volume 39, Issue 6, 2017
14. Zhang Xin, Yang Ning, Cai Wei, etc The effect of alanyl glutamine on changes in intestinal permeability in mice with cerebral ischemia-reperfusion injury Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, Volume 2l, Issue 2, February 2019
15. Wang Xiaodong, Wang Ying, Wang Caixia et al. investigated the role of 5-HT1A and 5-HT3 receptors in sevoflurane induced neurotoxicity in aged rats Chinese Journal of Anesthesiology, Volume 41, Issue 5, May 2021
16. Li Hao, Kong Gangcheng, Zhuang Quan, etc Improvement of surgical process and summary of experience in mouse heart transplantation model Chinese Journal of Transplantation (Electronic Edition), Volume 12, Issue 1, February 2018
17. Liu Chengling, Wang Yilin, Zhang Xuan Study on the animal model of psoriasis like dermatitis induced by streptococcal improvement of imiquimod Journal of PLA Medical College, January 2022, 43 (1)
18. Zhuangzi Rui, Wang Mingliang, Peng Yunru, etc Study on the preventive and therapeutic effects of C21 steroidal glycosides from Scutellaria baicalensis on liver and kidney fibrosis in rats through the TLR4 pathway Chinese Journal of Traditional Chinese Medicine, Volume 46, Issue 11, June 2021
19. Li Feng, Xu Mengmeng, Wang Muyun, etc Experimental study on establishing a mouse model of pulmonary fibrosis combined with emphysema Chinese Journal of Respiratory and Critical Care, Volume 17, Issue 6, November 2018
20. Shi Kaiyan, Zhang Chunxue, Wang Yijing, etc The effect of human umbilical cord mesenchymal stem cells on neurological function and neuroinflammation in mice with cerebral ischemia-reperfusion injury Journal of Tongji University (Medical Edition), Volume 41, Issue 5, October 2020
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